Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice

JongDae Shin, Michael Bossenz, Young Chung, Hong Ma, Meg Byron, Naoko Taniguchi-Ishigaki, Xiaochun Zhu, Baowei Jiao, Lisa L. Hall, Michael R. Green, Stephen N. Jones, Irm Hermans-Borgmeyer, Jeanne B. Lawrence and Ingolf Bach ()
Additional contact information
JongDae Shin: Program in Gene Function and Expression, University of Massachusetts Medical School (UMMS)
Michael Bossenz: Centre for Molecular Neurobiology, University of Hamburg
Young Chung: Stem Cell and Regenerative Medicine International, Inc.
Hong Ma: Program in Gene Function and Expression, University of Massachusetts Medical School (UMMS)
Meg Byron: UMMS
Naoko Taniguchi-Ishigaki: Program in Gene Function and Expression, University of Massachusetts Medical School (UMMS)
Xiaochun Zhu: Program in Gene Function and Expression, University of Massachusetts Medical School (UMMS)
Baowei Jiao: Program in Gene Function and Expression, University of Massachusetts Medical School (UMMS)
Lisa L. Hall: UMMS
Michael R. Green: Program in Gene Function and Expression, University of Massachusetts Medical School (UMMS)
Stephen N. Jones: UMMS
Irm Hermans-Borgmeyer: Centre for Molecular Neurobiology, University of Hamburg
Jeanne B. Lawrence: UMMS
Ingolf Bach: Program in Gene Function and Expression, University of Massachusetts Medical School (UMMS)

Nature, 2010, vol. 467, issue 7318, 977-981

Abstract: Early X-chromosome silencing To ensure that female mammals do not have an excess of X-chromosome gene products, one of the two X chromosomes present in each cell is silenced. During embryogenesis, the imprinted form of this X-chromosome inactivation (XCI) process selectively silences the paternal X following the detection of Xist RNA expression on the paternal X chromosome (Xp) at about the four-cell stage of embryonic development. Later, an embryonic form of XCI occurs in the developing blastocyst of the embryo proper, inactivating either the paternal or maternal X chromosome at random. Using mouse genetics, Shin et al. show that maternal deposits of Rnf12/RLIM ubiquitin ligase are crucial in the initiation of the initial process, but not in the later random X inactivation.

Date: 2010
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DOI: 10.1038/nature09457

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