TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

Xiaohua Su, Deepavali Chakravarti, Min Soon Cho, Lingzhi Liu, Young Jin Gi, Yu-Li Lin, Marco L. Leung, Adel El-Naggar, Chad J. Creighton, Milind B. Suraokar, Ignacio Wistuba and Elsa R. Flores ()
Additional contact information
Xiaohua Su: The University of Texas M. D. Anderson Cancer Center
Deepavali Chakravarti: The University of Texas M. D. Anderson Cancer Center
Min Soon Cho: The University of Texas M. D. Anderson Cancer Center
Lingzhi Liu: The University of Texas M. D. Anderson Cancer Center
Young Jin Gi: The University of Texas M. D. Anderson Cancer Center
Yu-Li Lin: The University of Texas M. D. Anderson Cancer Center
Marco L. Leung: The University of Texas M. D. Anderson Cancer Center
Adel El-Naggar: The University of Texas M. D. Anderson Cancer Center
Chad J. Creighton: Dan L. Duncan Cancer Center, Baylor College of Medicine
Milind B. Suraokar: The University of Texas M. D. Anderson Cancer Center
Ignacio Wistuba: The University of Texas M. D. Anderson Cancer Center
Elsa R. Flores: The University of Texas M. D. Anderson Cancer Center

Nature, 2010, vol. 467, issue 7318, 986-990

Abstract: TAp63 tumour suppression via Dicer The endoribonuclease Dicer is a key factor in the production of microRNAs. The deregulation of microRNA expression and potentially Dicer itself have been implicated in cancer. Elsa Flores and colleagues now show that TAp63, a member of the p53 family of tumour suppressors, suppresses tumorigenesis and metastasis by directly controlling the expression of Dicer and Dicer-regulated microRNAs.

Date: 2010
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DOI: 10.1038/nature09459

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