Satellite phage TLCφ enables toxigenic conversion by CTX phage through dif site alteration

Faizule Hassan, M. Kamruzzaman, John J. Mekalanos and Shah M. Faruque ()
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Faizule Hassan: Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka-1212, Bangladesh
M. Kamruzzaman: Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka-1212, Bangladesh
John J. Mekalanos: Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
Shah M. Faruque: Molecular Genetics Laboratory, International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka-1212, Bangladesh

Nature, 2010, vol. 467, issue 7318, 982-985

Abstract: The evolution of virulent Vibrio cholerae It has been known since the 1990s that the cholera toxin genes in Vibrio cholerae are found in the integrated bacteriophage CTXΦ, located in the V. cholerae genome adjacent to toxin-linked cryptic (TLC), a chromosomal DNA element of unknown function. TLC is now shown to correspond to the genome of TLCΦ, a satellite filamentous phage that uses the morphogenesis genes of a third filamentous phage (fs2Φ) to form infectious particles. By reconstructing the events that lead to the acquisition of phage DNA and comparing these to the genome of pandemic strains, Hassan et al. obtain a model of how virulent V. cholerae strains evolve to become successful human pathogens.

Date: 2010
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DOI: 10.1038/nature09469

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