Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

Sheau-Fang Ng, Ruby C. Y. Lin, D. Ross Laybutt, Romain Barres, Julie A. Owens and Margaret J. Morris ()
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Sheau-Fang Ng: School of Medical Sciences, University of New South Wales, New South Wales
Ruby C. Y. Lin: Ramaciotti Centre for Gene Function Analysis and School of Biotechnology and Biomolecular Sciences, University of New South Wales, New South Wales
D. Ross Laybutt: Garvan Institute of Medical Research
Romain Barres: School of Medical Sciences, University of New South Wales
Julie A. Owens: School of Paediatrics and Reproductive Health, University of Adelaide
Margaret J. Morris: School of Medical Sciences, University of New South Wales, New South Wales

Nature, 2010, vol. 467, issue 7318, 963-966

Abstract: Paternal diet linked to glucose intolerance in daughters Childhood obesity and diabetes are closely related to these conditions in either parent, but how the father contributes is unclear. A study in rats shows that normal females mated with obese, glucose-intolerant fathers on a high-fat diet produce female offspring who develop glucose intolerance due to impaired insulin secretion and pancreatic function. This is the first report in any species that a father's diet can initiate progression to diabetes in his offspring. The work highlights a novel role for environmentally induced paternal factors in influencing metabolic disease in offspring and in the growing epidemics of obesity and diabetes.

Date: 2010
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DOI: 10.1038/nature09491

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