Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo

Christel Rouget, Catherine Papin, Anthony Boureux, Anne-Cécile Meunier, Bénédicte Franco, Nicolas Robine, Eric C. Lai, Alain Pelisson and Martine Simonelig ()
Additional contact information
Christel Rouget: mRNA Regulation and Development, Institute of Human Genetics, CNRS UPR1142, 141 rue de la Cardonille, Cedex 5, 34396 Montpellier, France
Catherine Papin: mRNA Regulation and Development, Institute of Human Genetics, CNRS UPR1142, 141 rue de la Cardonille, Cedex 5, 34396 Montpellier, France
Anthony Boureux: CRBM, UMR5237, Université Montpellier II, CNRS, 1919 route de Mende, 34293 Montpellier, France
Anne-Cécile Meunier: mRNA Regulation and Development, Institute of Human Genetics, CNRS UPR1142, 141 rue de la Cardonille, Cedex 5, 34396 Montpellier, France
Bénédicte Franco: mRNA Regulation and Development, Institute of Human Genetics, CNRS UPR1142, 141 rue de la Cardonille, Cedex 5, 34396 Montpellier, France
Nicolas Robine: Sloan-Kettering Institute, 1017 Rockefeller Research Laboratories, 1275 York Avenue, New York, New York 10065, USA
Eric C. Lai: Sloan-Kettering Institute, 1017 Rockefeller Research Laboratories, 1275 York Avenue, New York, New York 10065, USA
Alain Pelisson: RNA Silencing and Control of Transposition, Institute of Human Genetics, CNRS UPR1142, 141 rue de la Cardonille, Cedex 5, 34396 Montpellier, France
Martine Simonelig: mRNA Regulation and Development, Institute of Human Genetics, CNRS UPR1142, 141 rue de la Cardonille, Cedex 5, 34396 Montpellier, France

Nature, 2010, vol. 467, issue 7319, 1128-1132

Abstract: piRNAs keep Nanos in check Small RNAs of the piRNA (Piwi-associated RNA) class have various functions in the germline — repressing transposable elements, maintaining germline stem cells and promoting genome stability. Rouget et al. have now uncovered a function for piRNAs outside the germline, in the fruit fly embryo. Specifically, piRNAs that are complementary to a sequence in the 3′-untranslated region of an mRNA for the embryonic posterior morphogen Nanos facilitate adenylation of the mRNA and its subsequent decay. Without piRNAs, Nanos accumulates and developmental defects result.

Date: 2010
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DOI: 10.1038/nature09465

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