Structural basis of semaphorin–plexin signalling

Bert J. C. Janssen, Ross A. Robinson, Francesc Pérez-Brangulí, Christian H. Bell, Kevin J. Mitchell, Christian Siebold and E. Yvonne Jones ()
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Bert J. C. Janssen: Wellcome Trust Centre for Human Genetics, University of Oxford
Ross A. Robinson: Wellcome Trust Centre for Human Genetics, University of Oxford
Francesc Pérez-Brangulí: Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin
Christian H. Bell: Wellcome Trust Centre for Human Genetics, University of Oxford
Kevin J. Mitchell: Smurfit Institute of Genetics and Institute of Neuroscience, Trinity College Dublin
Christian Siebold: Wellcome Trust Centre for Human Genetics, University of Oxford
E. Yvonne Jones: Wellcome Trust Centre for Human Genetics, University of Oxford

Nature, 2010, vol. 467, issue 7319, 1118-1122

Abstract: Plexin signalling in cell guidance The semaphorin–plexin signalling system is an important cell-guidance cue. It has a central role in the development and homeostasis of a broad range of tissues, and is widely studied for its role in neural connectivity, cancer, cell migration and immune responses. In this issue of Nature, two groups report crystal structures of key components of the semaphorin–plexin system, and propose a mechanism for plexin signalling based on their findings. Janssen et al. determined the crystal structures of complexes of the semaphorin-binding regions of plexins B1 and A2 with their cognate semaphorin ectodomains. Nogi et al. present crystal structures of complexes of semaphorin 6A and plexin A2 ectodomains.

Date: 2010
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DOI: 10.1038/nature09468

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