Structural basis for semaphorin signalling through the plexin receptor

Terukazu Nogi, Norihisa Yasui, Emiko Mihara, Yukiko Matsunaga, Masanori Noda, Naoya Yamashita, Toshihiko Toyofuku, Susumu Uchiyama, Yoshio Goshima, Atsushi Kumanogoh and Junichi Takagi ()
Additional contact information
Terukazu Nogi: Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan
Norihisa Yasui: Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan
Emiko Mihara: Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan
Yukiko Matsunaga: Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan
Masanori Noda: Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan
Naoya Yamashita: Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa, Yokohama 236-0004, Japan
Toshihiko Toyofuku: Immunology Frontier Research Center, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan
Susumu Uchiyama: Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan
Yoshio Goshima: Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa, Yokohama 236-0004, Japan
Atsushi Kumanogoh: Immunology Frontier Research Center, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan
Junichi Takagi: Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan

Nature, 2010, vol. 467, issue 7319, 1123-1127

Abstract: Plexin signalling in cell guidance The semaphorin–plexin signalling system is an important cell-guidance cue. It has a central role in the development and homeostasis of a broad range of tissues, and is widely studied for its role in neural connectivity, cancer, cell migration and immune responses. In this issue of Nature, two groups report crystal structures of key components of the semaphorin–plexin system, and propose a mechanism for plexin signalling based on their findings. Janssen et al. determined the crystal structures of complexes of the semaphorin-binding regions of plexins B1 and A2 with their cognate semaphorin ectodomains. Nogi et al. present crystal structures of complexes of semaphorin 6A and plexin A2 ectodomains.

Date: 2010
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DOI: 10.1038/nature09473

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