Fine-scale recombination rate differences between sexes, populations and individuals

Augustine Kong (), Gudmar Thorleifsson, Daniel F. Gudbjartsson, Gisli Masson, Asgeir Sigurdsson, Aslaug Jonasdottir, G. Bragi Walters, Adalbjorg Jonasdottir, Arnaldur Gylfason, Kari Th. Kristinsson, Sigurjon A. Gudjonsson, Michael L. Frigge, Agnar Helgason, Unnur Thorsteinsdottir and Kari Stefansson ()
Additional contact information
Augustine Kong: deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland
Gudmar Thorleifsson: deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland
Daniel F. Gudbjartsson: deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland
Gisli Masson: deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland
Asgeir Sigurdsson: deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland
Aslaug Jonasdottir: deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland
G. Bragi Walters: deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland
Adalbjorg Jonasdottir: deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland
Arnaldur Gylfason: deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland
Kari Th. Kristinsson: deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland
Sigurjon A. Gudjonsson: deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland
Michael L. Frigge: deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland
Agnar Helgason: deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland
Unnur Thorsteinsdottir: deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland
Kari Stefansson: deCODE genetics, Sturlugata 8, 101 Reykjavík, Iceland

Nature, 2010, vol. 467, issue 7319, 1099-1103

Abstract: Recombination maps reveal differences between the sexes High-resolution recombination maps serve many purposes in genetic research. The currently available maps, which use linkage disequilibrium patterns of high-density SNP (single nucleotide polymorphism) data from the HapMap project, have proved to be very useful. But they have some limitations; for instance, they do not provide information on differences in recombination characteristics between and within the sexes. A team at biopharmaceutical firm deCODE genetics in Reykjavik has used genome-wide SNP data from more than 15,000 parent–offspring pairs to construct the first recombination maps based on directly observed recombination events, providing resolution down to 10 kilobases. Their data reveal interesting recombination differences between the sexes. In males, for example, recombination tends to shuffle exons, whereas in females it generates new combinations of nearby genes. Comparisons of these maps with those based on linkage disequilibrium reveal previously unrecognized differences between populations in Europe, Africa and the United States.

Date: 2010
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DOI: 10.1038/nature09525

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