A methyl transferase links the circadian clock to the regulation of alternative splicing

Sabrina E. Sanchez, Ezequiel Petrillo, Esteban J. Beckwith, Xu Zhang, Matias L. Rugnone, C. Esteban Hernando, Juan C. Cuevas, Micaela A. Godoy Herz, Ana Depetris-Chauvin, Craig G. Simpson, John W. S. Brown, Pablo D. Cerdán, Justin O. Borevitz, Paloma Mas, M. Fernanda Ceriani, Alberto R. Kornblihtt and Marcelo J. Yanovsky ()
Additional contact information
Sabrina E. Sanchez: IFEVA, Facultad de Agronomía, UBA-CONICET
Ezequiel Petrillo: IFIBYNE, FCEyN, UBA-CONICET
Esteban J. Beckwith: Fundación Instituto Leloir, IIBBA-CONICET
Xu Zhang: University of Chicago
Matias L. Rugnone: IFEVA, Facultad de Agronomía, UBA-CONICET
C. Esteban Hernando: IFEVA, Facultad de Agronomía, UBA-CONICET
Juan C. Cuevas: Centre for Research in Agricultural Genomics (CRAG), Consortium CSIC-IRTA-UAB
Micaela A. Godoy Herz: IFIBYNE, FCEyN, UBA-CONICET
Ana Depetris-Chauvin: Fundación Instituto Leloir, IIBBA-CONICET
Craig G. Simpson: Genetics Programme, SCRI, Invergowrie
John W. S. Brown: Genetics Programme, SCRI, Invergowrie
Pablo D. Cerdán: Fundación Instituto Leloir, IIBBA-CONICET
Justin O. Borevitz: University of Chicago
Paloma Mas: Centre for Research in Agricultural Genomics (CRAG), Consortium CSIC-IRTA-UAB
M. Fernanda Ceriani: Fundación Instituto Leloir, IIBBA-CONICET
Alberto R. Kornblihtt: IFIBYNE, FCEyN, UBA-CONICET
Marcelo J. Yanovsky: IFEVA, Facultad de Agronomía, UBA-CONICET

Nature, 2010, vol. 468, issue 7320, 112-116

Abstract: Time for some RNA editing Various biological processes are driven by the day/night cycle to occur at a certain time of day. One way the circadian system exerts these effects is through post-transcriptional regulation. Sanchez et al. show that PRMT5, a protein that transfers methyl groups onto subunits of the spliceosome — the complex that cuts non-protein-coding stretches from pre-RNA — is regulated by the light/dark cycle. This affects alternative splicing of some genes, making them subject to circadian control. This work shows one way by which the environment alters gene expression.

Date: 2010
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DOI: 10.1038/nature09470

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