Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke

Andrew N. Clarkson, Ben S. Huang, Sarah E. MacIsaac, Istvan Mody and S. Thomas Carmichael ()
Additional contact information
Andrew N. Clarkson: The David Geffen School of Medicine at UCLA, 635 Charles Young Drive South, Los Angeles, California 90095, USA
Ben S. Huang: The David Geffen School of Medicine at UCLA, 635 Charles Young Drive South, Los Angeles, California 90095, USA
Sarah E. MacIsaac: The David Geffen School of Medicine at UCLA, 635 Charles Young Drive South, Los Angeles, California 90095, USA
Istvan Mody: The David Geffen School of Medicine at UCLA, 635 Charles Young Drive South, Los Angeles, California 90095, USA
S. Thomas Carmichael: The David Geffen School of Medicine at UCLA, 635 Charles Young Drive South, Los Angeles, California 90095, USA

Nature, 2010, vol. 468, issue 7321, 305-309

Abstract: A target for boosting stroke recovery Stroke is a leading cause of disability because of the brain's limited capacity for recovery. The functional recovery that does occur derives in part from the transfer of brain function to the tissue bordering the stroke site. A study in a mouse model shows that stroke reduces excitation in neurons adjacent to the stroke site by impairing transport of GABA, leading to a build-up of this inhibitory neurotransmitter. Genetic or pharmacological blockade of extrasynaptic GABAA receptors improves behavioural recovery. Critically, the treatment remains successful when there is a delay between stroke and therapy. This work identifies novel pharmacological targets for neural recovery after stroke and possibly other brain injuries.

Date: 2010
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/nature09511 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:468:y:2010:i:7321:d:10.1038_nature09511

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09511

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().