The mechanism of retroviral integration from X-ray structures of its key intermediates

Goedele N. Maertens, Stephen Hare and Peter Cherepanov ()
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Goedele N. Maertens: Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG, UK
Stephen Hare: Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG, UK
Peter Cherepanov: Imperial College London, St Mary’s Campus, Norfolk Place, London W2 1PG, UK

Nature, 2010, vol. 468, issue 7321, 326-329

Abstract: Retroviral integration mechanisms Retroviruses such as HIV need to insert their genome into the host genome in order to replicate. This process is mediated by a tetramer of the virus-encoded integrase protein. Earlier this year, Peter Cherepanov and colleagues reported the structure of a related integrase from prototype foamy virus bound to the cleaved viral DNA ends, a complex known as the intasome. Now they have solved the structure of the intasome interacting with the target host DNA, before and after it is cleaved. This work reveals new details of the integration process that could be useful in designing improved inhibitors of HIV.

Date: 2010
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DOI: 10.1038/nature09517

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