Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

Norman Pavelka, Giulia Rancati, Jin Zhu, William D. Bradford, Anita Saraf, Laurence Florens, Brian W. Sanderson, Gaye L. Hattem and Rong Li ()
Additional contact information
Norman Pavelka: Stowers Institute for Medical Research
Giulia Rancati: Stowers Institute for Medical Research
Jin Zhu: Stowers Institute for Medical Research
William D. Bradford: Stowers Institute for Medical Research
Anita Saraf: Stowers Institute for Medical Research
Laurence Florens: Stowers Institute for Medical Research
Brian W. Sanderson: Stowers Institute for Medical Research
Gaye L. Hattem: Stowers Institute for Medical Research
Rong Li: Stowers Institute for Medical Research

Nature, 2010, vol. 468, issue 7321, 321-325

Abstract: Positive effects of aneuploidy Aneuploidy, the presence of an abnormal number of chromosomes, has been associated with developmental defects and cancer, but also with adaptive evolution in experimental organisms. Recent studies raised doubts over whether aneuploidy affects gene expression at the proteome level or whether it can bring phenotypic variation and improved fitness over euploid counterparts. A profiling study of a large set of aneuploid yeast strains grown under a variety of conditions demonstrates that aneuploidy can affect both the transcriptome and the proteome, and generate significant phenotypic variation that can lead to fitness gains.

Date: 2010
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DOI: 10.1038/nature09529

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