A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity

Na-Yu Chia, Yun-Shen Chan, Bo Feng, Xinyi Lu, Yuriy L. Orlov, Dimitri Moreau, Pankaj Kumar, Lin Yang, Jianming Jiang, Mei-Sheng Lau, Mikael Huss, Boon-Seng Soh, Petra Kraus, Pin Li, Thomas Lufkin, Bing Lim, Neil D. Clarke, Frederic Bard () and Huck-Hui Ng ()
Additional contact information
Na-Yu Chia: Gene Regulation Laboratory, Genome Institute of Singapore
Yun-Shen Chan: Gene Regulation Laboratory, Genome Institute of Singapore
Bo Feng: Gene Regulation Laboratory, Genome Institute of Singapore
Xinyi Lu: Gene Regulation Laboratory, Genome Institute of Singapore
Yuriy L. Orlov: Computational and Systems Biology group, Genome Institute of Singapore
Dimitri Moreau: Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673
Pankaj Kumar: Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673
Lin Yang: Gene Regulation Laboratory, Genome Institute of Singapore
Jianming Jiang: Gene Regulation Laboratory, Genome Institute of Singapore
Mei-Sheng Lau: Gene Regulation Laboratory, Genome Institute of Singapore
Mikael Huss: Computational and Systems Biology group, Genome Institute of Singapore
Boon-Seng Soh: Stem Cell and Developmental Biology, Genome Institute of Singapore
Petra Kraus: Stem Cell and Developmental Biology, Genome Institute of Singapore
Pin Li: Stem Cell and Developmental Biology, Genome Institute of Singapore
Thomas Lufkin: Stem Cell and Developmental Biology, Genome Institute of Singapore
Bing Lim: Stem Cell and Developmental Biology, Genome Institute of Singapore
Neil D. Clarke: Computational and Systems Biology group, Genome Institute of Singapore
Frederic Bard: Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, Singapore 138673
Huck-Hui Ng: Gene Regulation Laboratory, Genome Institute of Singapore

Nature, 2010, vol. 468, issue 7321, 316-320

Abstract: Screen test for stem-cell cues If the full potential of human embryonic stem (ES) cells in research and clinical applications is to be realized, we need a detailed understanding of the genetic network that governs their unique properties. A genome-wide RNA interference screen identifies a wealth of regulators of self-renewal and pluripotency properties in human embryonic stem cells. PRDM14, for example, represents a key transcription factor required for the maintenance of human ES cell identity and reprogramming of somatic cells to pluripotency.

Date: 2010
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DOI: 10.1038/nature09531

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