Glial and neuronal control of brain blood flow

David Attwell (), Alastair M. Buchan, Serge Charpak, Martin Lauritzen, Brian A. MacVicar and Eric A. Newman
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David Attwell: Physiology and Pharmacology, University College London
Alastair M. Buchan: Acute Stroke Programme, University of Oxford
Serge Charpak: INSERM U603; CNRS UMR 8154; Laboratory of Neurophysiology and New Microscopies, Université Paris Descartes
Martin Lauritzen: Institute for Neuroscience and Pharmacology, University of Copenhagen & Glostrup Hospital
Brian A. MacVicar: University of British Columbia
Eric A. Newman: University of Minnesota

Nature, 2010, vol. 468, issue 7321, 232-243

Abstract: Abstract Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for interpreting functional imaging scans of brains, and for developing treatments for neurological disorders. It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles. These conceptual shifts in our understanding of cerebral blood flow control have important implications for the development of new therapeutic approaches.

Date: 2010
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DOI: 10.1038/nature09613

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