Molecular coupling of Tsix regulation and pluripotency

Pablo Navarro (), Andrew Oldfield, Julie Legoupi, Nicola Festuccia, Agnès Dubois, Mikael Attia, Jon Schoorlemmer, Claire Rougeulle, Ian Chambers and Philip Avner ()
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Pablo Navarro: Unité de Génétique Moléculaire Murine, URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France
Andrew Oldfield: Unité de Génétique Moléculaire Murine, URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France
Julie Legoupi: Unité de Génétique Moléculaire Murine, URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France
Nicola Festuccia: Medical Research Council (MRC) Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh
Agnès Dubois: Unité de Génétique Moléculaire Murine, URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France
Mikael Attia: Unité de Génétique Moléculaire Murine, URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France
Jon Schoorlemmer: ARAID Foundation and Instituto Aragonés de Ciencias de la Salud, Facultad de Veterinaria
Claire Rougeulle: Unité de Génétique Moléculaire Murine, URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France
Ian Chambers: Medical Research Council (MRC) Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh
Philip Avner: Unité de Génétique Moléculaire Murine, URA 2578, Institut Pasteur, 75724 Paris Cedex 15, France

Nature, 2010, vol. 468, issue 7322, 457-460

Abstract: Tsix regulation and pluripotency Reprogramming of X-chromosome inactivation during the acquisition of pluripotency is accompanied by repression of Xist, the trigger of X-inactivation, and by upregulation of its antisense counterpart Tsix, which triggers resetting of the Xist locus. In undifferentiated embryonic stem cells, key transcription factors that support pluripotency — Nanog, Oct4 and Sox2 — repress Xist transcription. Here, upregulation of Tsix in embryonic stem cells is shown to depend on a different subset of pluripotency factors — Rex1, Klf4 and c-Myc. Therefore, two distinct embryonic-stem-cell-specific complexes couple reprogramming of X-inactivation to pluripotency.

Date: 2010
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DOI: 10.1038/nature09496

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