Integrating carbon–halogen bond formation into medicinal plant metabolism

Weerawat Runguphan, Xudong Qu and Sarah E. O’Connor ()
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Weerawat Runguphan: Massachusetts Institute of Technology
Xudong Qu: Massachusetts Institute of Technology
Sarah E. O’Connor: Massachusetts Institute of Technology

Nature, 2010, vol. 468, issue 7322, 461-464

Abstract: Gilding the periwinkle Medicinal plants produce a variety of structurally complex, pharmaceutically important products, but generate relatively few halogenated compounds. Runguphan et al. remedy that omission by introducing the biosynthetic machinery responsible for chlorination in soil bacteria into the genome of the periwinkle, Catharanthus roseus. The prokaryotic halogenases function within the plant cells to generate chlorinated tryptophan, which is then utilized by the monoterpene indole alkaloid metabolic pathways to yield chlorinated alkaloids.

Date: 2010
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DOI: 10.1038/nature09524

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