L1 retrotransposition in neurons is modulated by MeCP2

Alysson R. Muotri (), Maria C. N. Marchetto, Nicole G. Coufal, Ruth Oefner, Gene Yeo, Kinichi Nakashima and Fred H. Gage ()
Additional contact information
Alysson R. Muotri: University of California San Diego, School of Medicine, Stem Cell Program
Maria C. N. Marchetto: Laboratory of Genetics, The Salk Institute for Biological Studies
Nicole G. Coufal: Laboratory of Genetics, The Salk Institute for Biological Studies
Ruth Oefner: Laboratory of Genetics, The Salk Institute for Biological Studies
Gene Yeo: University of California San Diego, School of Medicine, Stem Cell Program, 9500 Gilman Dr, La Jolla, California 92093-0695, USA
Kinichi Nakashima: Laboratory of Molecular Neuroscience, Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma 630-0101, Japan
Fred H. Gage: Laboratory of Genetics, The Salk Institute for Biological Studies

Nature, 2010, vol. 468, issue 7322, 443-446

Abstract: Retrotransposition in neurons L1 retrotransposons are dynamically regulated and active genomic elements that affect gene expression and neuronal function throughout brain development. According to a new study by Alysson Muotri and colleagues, the absence of MeCP2, a modulator of DNA methylation implicated in several neurodevelopmental disorders, increases L1 retrotransposon activity in rodent models. This increase in susceptibility to L1 retrotransposition is duplicated in iPS cells derived from patients with Rett syndrome. These data correlations suggest that disease-related genetic mutations may influence L1 retrotransposon activity, adding another layer of complexity to our understanding of molecular neurological disorders.

Date: 2010
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature09544 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:468:y:2010:i:7322:d:10.1038_nature09544

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09544

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().