Pericytes regulate the blood–brain barrier

Annika Armulik (), Guillem Genové, Maarja Mäe, Maya H. Nisancioglu, Elisabet Wallgard, Colin Niaudet, Liqun He, Jenny Norlin, Per Lindblom, Karin Strittmatter, Bengt R. Johansson and Christer Betsholtz ()
Additional contact information
Annika Armulik: Karolinska Institute, Scheeles väg 2, SE-171 77 Stockholm, Sweden
Guillem Genové: Karolinska Institute, Scheeles väg 2, SE-171 77 Stockholm, Sweden
Maarja Mäe: Karolinska Institute, Scheeles väg 2, SE-171 77 Stockholm, Sweden
Maya H. Nisancioglu: Karolinska Institute, Scheeles väg 2, SE-171 77 Stockholm, Sweden
Elisabet Wallgard: Karolinska Institute, Scheeles väg 2, SE-171 77 Stockholm, Sweden
Colin Niaudet: Karolinska Institute, Scheeles väg 2, SE-171 77 Stockholm, Sweden
Liqun He: Karolinska Institute, Scheeles väg 2, SE-171 77 Stockholm, Sweden
Jenny Norlin: Karolinska Institute, Scheeles väg 2, SE-171 77 Stockholm, Sweden
Per Lindblom: AstraZeneca AB, Clinical Development, SE-431 83 Mölndal, Sweden
Karin Strittmatter: Karolinska Institute, Scheeles väg 2, SE-171 77 Stockholm, Sweden
Bengt R. Johansson: The Electron Microscopy Unit, Institute for Biomedicine, The Sahlgrenska Academy, University of Gothenburg, PO Box 420, SE-405 30 Gothenburg, Sweden
Christer Betsholtz: Karolinska Institute, Scheeles väg 2, SE-171 77 Stockholm, Sweden

Nature, 2010, vol. 468, issue 7323, 557-561

Abstract: Building the blood–brain barrier The blood–brain barrier is a gatekeeper between the central nervous system and the rest of the body, and is made up of vascular endothelial cells. Previous work upheld the notion that the barrier was formed postnatally as a result of signalling from non-neuronal cells called astrocytes to endothelial cells. Now, two independent studies demonstrate that the barrier is in fact formed during embryogenesis, with the critical factor being the interaction between blood-vessel-surrounding cells called pericytes and epithelial cells. A better understanding of the tight relationship between pericytes, neuroendothelial cells and astrocytes in blood–brain barrier function will contribute to our understanding of the breakdown of the barrier during central nervous system injury and disease.

Date: 2010
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DOI: 10.1038/nature09522

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