Lee et al. reply

Jin Hyung Lee (), Remy Durand (), Viviana Gradinaru (), Feng Zhang (), Inbal Goshen (), Dae-Shik Kim, Lief E. Fenno (), Charu Ramakrishnan () and Karl Deisseroth ()
Additional contact information
Jin Hyung Lee: Psychiatry and Biobehavioral Sciences, Bioengineering, and Radiology, University of California
Remy Durand: Stanford University
Viviana Gradinaru: Stanford University
Feng Zhang: Stanford University
Inbal Goshen: Stanford University
Dae-Shik Kim: Korea Advanced Institute of Science and Technology (KAIST)
Lief E. Fenno: Stanford University
Charu Ramakrishnan: Stanford University
Karl Deisseroth: Stanford University

Nature, 2010, vol. 468, issue 7323, E4-E5

Abstract: Abstract Replying to N. K. Logothetis Nature 468, 10.1038/nature09532 (2010) This is a welcome opportunity to discuss ofMRI, a technology for testing the causal and global impact of defined cell populations in vivo1. The accompanying Comment2 reviews well-known neuroanatomy, but does seem, in its entirety, to be founded on a suggestion that, after experiments were conducted to drive a defined circuit element and measure resulting BOLD signals1, we concluded that no other contributory circuit element was recruited by the driven population. This was not the case, however, as correctly understood by others in the fMRI community3,4,5 and as explained in the paper (for example, “contributions from additional cells and processes downstream of the defined optically triggered population are expected and indeed represent an important aspect of this approach”1). Moreover, the complexity of the brain dictates that such possible contributory mechanisms are more numerous than listed in the Comment2, including many other circuit and feedback mechanisms and classes of cells within neural circuitry6,7,8,9,10. As was discussed1, this is one of the most important and useful aspects of the ofMRI approach. https://www.nature.com/articles/nature09532

Date: 2010
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DOI: 10.1038/nature09533

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