Tension directly stabilizes reconstituted kinetochore-microtubule attachments

Bungo Akiyoshi, Krishna K. Sarangapani, Andrew F. Powers, Christian R. Nelson, Steve L. Reichow, Hugo Arellano-Santoyo, Tamir Gonen, Jeffrey A. Ranish, Charles L. Asbury () and Sue Biggins ()
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Bungo Akiyoshi: Fred Hutchinson Cancer Research Center
Krishna K. Sarangapani: University of Washington
Andrew F. Powers: University of Washington
Christian R. Nelson: Fred Hutchinson Cancer Research Center
Steve L. Reichow: University of Washington
Hugo Arellano-Santoyo: Fred Hutchinson Cancer Research Center
Tamir Gonen: University of Washington
Jeffrey A. Ranish: Institute for Systems Biology
Charles L. Asbury: University of Washington
Sue Biggins: Fred Hutchinson Cancer Research Center

Nature, 2010, vol. 468, issue 7323, 576-579

Abstract: Stability of kinetochore–microtubule binding The kinetochore is the large protein complex that assembles on centromeric DNA to mediate chromosome separation. For decades, researchers have tried to isolate whole functional kinetochores without success. Sue Biggins and colleagues now report the first purification of functional kinetochores. They also show that kinetochore particles maintain load-bearing associations with assembling and disassembling microtubules, and that tension directly increases the lifetimes of the attachments. These results provide evidence that tension selectively stabilizes kinetochore–microtubule interactions.

Date: 2010
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DOI: 10.1038/nature09594

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