Sugar transporters for intercellular exchange and nutrition of pathogens

Li-Qing Chen, Bi-Huei Hou, Sylvie Lalonde, Hitomi Takanaga, Mara L. Hartung, Xiao-Qing Qu, Woei-Jiun Guo, Jung-Gun Kim, William Underwood, Bhavna Chaudhuri, Diane Chermak, Ginny Antony, Frank F. White, Shauna C. Somerville, Mary Beth Mudgett and Wolf B. Frommer ()
Additional contact information
Li-Qing Chen: Carnegie Institution for Science
Bi-Huei Hou: Carnegie Institution for Science
Sylvie Lalonde: Carnegie Institution for Science
Hitomi Takanaga: Carnegie Institution for Science
Mara L. Hartung: Carnegie Institution for Science
Xiao-Qing Qu: Carnegie Institution for Science
Woei-Jiun Guo: Carnegie Institution for Science
Jung-Gun Kim: Stanford University, 228A Gilbert Bioscience Building, 371 Serra Mall, Stanford, California 94305, USA
William Underwood: Energy Bioscience Institute, 130 Calvin Hall, MC 5230
Bhavna Chaudhuri: Carnegie Institution for Science
Diane Chermak: Carnegie Institution for Science
Ginny Antony: Kansas State University
Frank F. White: Kansas State University
Shauna C. Somerville: Energy Bioscience Institute, 130 Calvin Hall, MC 5230
Mary Beth Mudgett: Stanford University, 228A Gilbert Bioscience Building, 371 Serra Mall, Stanford, California 94305, USA
Wolf B. Frommer: Carnegie Institution for Science

Nature, 2010, vol. 468, issue 7323, 527-532

Abstract: Abstract Sugar efflux transporters are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. Despite broad biological importance, the identity of sugar efflux transporters has remained elusive. Using optical glucose sensors, we identified a new class of sugar transporters, named SWEETs, and show that at least six out of seventeen Arabidopsis, two out of over twenty rice and two out of seven homologues in Caenorhabditis elegans, and the single copy human protein, mediate glucose transport. Arabidopsis SWEET8 is essential for pollen viability, and the rice homologues SWEET11 and SWEET14 are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter. Bacterial symbionts and fungal and bacterial pathogens induce the expression of different SWEET genes, indicating that the sugar efflux function of SWEET transporters is probably targeted by pathogens and symbionts for nutritional gain. The metazoan homologues may be involved in sugar efflux from intestinal, liver, epididymis and mammary cells.

Date: 2010
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DOI: 10.1038/nature09606

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