A dimorphic pheromone circuit in Drosophila from sensory input to descending output

Vanessa Ruta, Sandeep Robert Datta, Maria Luisa Vasconcelos, Jessica Freeland, Loren L. Looger and Richard Axel ()
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Vanessa Ruta: College of Physicians and Surgeons, Columbia University
Sandeep Robert Datta: College of Physicians and Surgeons, Columbia University
Maria Luisa Vasconcelos: College of Physicians and Surgeons, Columbia University
Jessica Freeland: College of Physicians and Surgeons, Columbia University
Loren L. Looger: Howard Hughes Medical Institute, Janelia Farm Research Campus
Richard Axel: College of Physicians and Surgeons, Columbia University

Nature, 2010, vol. 468, issue 7324, 686-690

Abstract: Male-versus-female response to a pheromone Innate differences between male and female behaviours must be inscribed in their respective genomes, but how these encode distinct neuronal circuits remains largely unknown. Focusing on sex-specific responses to the cVA pheromone in fruitflies, Richard Axel and colleagues have now identified a chain of four successive neurons carrying olfactory signals down to motor centres, with all male-to-female anatomical differences lying downstream of a conserved sensory cell. The techniques developed by the team should help others in the task of neuronal circuit mapping, which remains daunting even for the relatively simple fly brain.

Date: 2010
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DOI: 10.1038/nature09554

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