Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells

Boyi Gan, Jian Hu, Shan Jiang, Yingchun Liu, Ergün Sahin, Li Zhuang, Eliot Fletcher-Sananikone, Simona Colla, Y. Alan Wang, Lynda Chin and Ronald A. DePinho ()
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Boyi Gan: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Jian Hu: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Shan Jiang: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Yingchun Liu: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Ergün Sahin: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Li Zhuang: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Eliot Fletcher-Sananikone: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Simona Colla: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Y. Alan Wang: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Lynda Chin: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute
Ronald A. DePinho: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute

Nature, 2010, vol. 468, issue 7324, 701-704

Abstract: Lkb1 promotes haematopoietic stem cell survival Haematopoietic stem cells are very sensitive to energetic and oxidative stress, and modulation of the balance between their quiescence and proliferation is needed to respond to metabolic stress while preserving their long-term regenerative capacity. Three new studies show that the tumour suppressor and metabolic sensor Lkb1 has a crucial role in maintaining energy homeostasis in haematopoietic cells. Lkb1 is shown to be necessary for cell-cycle regulation as well as for energy homeostasis, and haematopoietic stem cells depend more acutely on Lkb1 than any other haematopoietic cells.

Date: 2010
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DOI: 10.1038/nature09595

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