Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

Lucia Ricci-Vitiani, Roberto Pallini (), Mauro Biffoni, Matilde Todaro, Gloria Invernici, Tonia Cenci, Giulio Maira, Eugenio Agostino Parati, Giorgio Stassi, Luigi Maria Larocca and Ruggero De Maria ()
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Lucia Ricci-Vitiani: Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299
Roberto Pallini: Catholic University of Rome, Largo Francesco Vito 1
Mauro Biffoni: Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299
Matilde Todaro: University of Palermo, Via Liborio Giuffrè 5
Gloria Invernici: U. O. Cerebrovascular Disease Cellular Neurobiology Laboratory, Fondazione IRCCS, Neurological Institute “Carlo Besta”, Via Celoria 11
Tonia Cenci: Institute of Pathology, Catholic University of Rome, Largo Francesco Vito 1
Giulio Maira: Catholic University of Rome, Largo Francesco Vito 1
Eugenio Agostino Parati: U. O. Cerebrovascular Disease Cellular Neurobiology Laboratory, Fondazione IRCCS, Neurological Institute “Carlo Besta”, Via Celoria 11
Giorgio Stassi: University of Palermo, Via Liborio Giuffrè 5
Luigi Maria Larocca: Institute of Pathology, Catholic University of Rome, Largo Francesco Vito 1
Ruggero De Maria: Oncology and Molecular Medicine, Istituto Superiore di Sanità, Viale Regina Elena 299

Nature, 2010, vol. 468, issue 7325, 824-828

Abstract: Tumour cells that supply their own blood Glioblastomas are aggressive brain cancers that are nourished by an extensive network of blood vessels. Two groups now show that glioblastoma cells can differentiate into functional endothelial cells as part of the tumour vasculature. These endothelial cells are characterized by the same genetic alterations as the glioblastoma cells and seem to be derived from glioblastoma stem-like cells. This work suggests that some putative cancer stem cells promote cancer growth both directly and indirectly, and may explain the failure of certain anti-angiogenic cancer drugs and aid the design of new therapies.

Date: 2010
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DOI: 10.1038/nature09557

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