Calcium-dependent phospholipid scrambling by TMEM16F

Jun Suzuki, Masato Umeda, Peter J. Sims and Shigekazu Nagata ()
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Jun Suzuki: Graduate School of Medicine, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan
Masato Umeda: Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan
Peter J. Sims: University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, New York 14642, USA
Shigekazu Nagata: Graduate School of Medicine, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan

Nature, 2010, vol. 468, issue 7325, 834-838

Abstract: Phospholipid scrambling The plasma membranes of eukaryotic cells have an asymmetrical distribution of phospholipids. Lipid asymmetry can be disrupted during biological processes such as apoptosis, when phosphatidylserine in the inner leaflet of the membrane is exposed on the outer membrane. It has been proposed that activation of a phospholipid scramblase catalyses bidirectional transbilayer movement of phospholipids, and now a protein corresponding to this activity has been identified as TMEM16F, a member of the TMEM16 family of transmembrane proteins. Furthermore, a patient with Scott syndrome, which results from a defect in phospholipid scrambling activity, was found to carry a mutation in the gene encoding TMEM16F.

Date: 2010
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DOI: 10.1038/nature09583

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