Glioblastoma stem-like cells give rise to tumour endothelium

Rong Wang, Kalyani Chadalavada, Jennifer Wilshire, Urszula Kowalik, Koos E. Hovinga, Adam Geber, Boris Fligelman, Margaret Leversha, Cameron Brennan and Viviane Tabar ()
Additional contact information
Rong Wang: Memorial Sloan Kettering Cancer Center
Kalyani Chadalavada: Molecular Cytogenetics, Memorial Sloan Kettering Cancer Center
Jennifer Wilshire: Flow Cytometry Core, Memorial Sloan Kettering Cancer Center
Urszula Kowalik: Memorial Sloan Kettering Cancer Center
Koos E. Hovinga: Memorial Sloan Kettering Cancer Center
Adam Geber: Memorial Sloan Kettering Cancer Center
Boris Fligelman: Memorial Sloan Kettering Cancer Center
Margaret Leversha: Molecular Cytogenetics, Memorial Sloan Kettering Cancer Center
Cameron Brennan: Memorial Sloan Kettering Cancer Center
Viviane Tabar: Memorial Sloan Kettering Cancer Center

Nature, 2010, vol. 468, issue 7325, 829-833

Abstract: Tumour cells that supply their own blood Glioblastomas are aggressive brain cancers that are nourished by an extensive network of blood vessels. Two groups now show that glioblastoma cells can differentiate into functional endothelial cells as part of the tumour vasculature. These endothelial cells are characterized by the same genetic alterations as the glioblastoma cells and seem to be derived from glioblastoma stem-like cells. This work suggests that some putative cancer stem cells promote cancer growth both directly and indirectly, and may explain the failure of certain anti-angiogenic cancer drugs and aid the design of new therapies.

Date: 2010
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DOI: 10.1038/nature09624

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