A phylogenetically based transcriptome age index mirrors ontogenetic divergence patterns

Tomislav Domazet-Lošo () and Diethard Tautz
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Tomislav Domazet-Lošo: Max-Planck-Institut für Evolutionsbiologie, August-Thienemannstrasse 2, 24306 Plön, Germany
Diethard Tautz: Max-Planck-Institut für Evolutionsbiologie, August-Thienemannstrasse 2, 24306 Plön, Germany

Nature, 2010, vol. 468, issue 7325, 815-818

Abstract: The hourglass: a classic embryological model for the genomics age The appearance of embryos in related species converges midway through development and diverges thereafter, a phenomenon known as the developmental hourglass. The hourglass model builds on classic observations by Karl Ernst von Baer, later popularized by Ernst Haeckel — Charles Darwin's champion in Germany. But is this 'phylotypic stage' real? Two groups use contrasting methodology to test — and provide support for — the model. Genes expressed during the phylotypic stage are both evolutionarily older and more conserved across the genus than those expressed at other stages.

Date: 2010
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DOI: 10.1038/nature09632

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