Gene expression divergence recapitulates the developmental hourglass model

Alex T. Kalinka, Karolina M. Varga, Dave T. Gerrard, Stephan Preibisch, David L. Corcoran, Julia Jarrells, Uwe Ohler, Casey M. Bergman and Pavel Tomancak ()
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Alex T. Kalinka: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany
Karolina M. Varga: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany
Dave T. Gerrard: Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
Stephan Preibisch: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany
David L. Corcoran: Institute for Genome Sciences and Policy, Duke University
Julia Jarrells: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany
Uwe Ohler: Institute for Genome Sciences and Policy, Duke University
Casey M. Bergman: Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
Pavel Tomancak: Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr. 108, 01307 Dresden, Germany

Nature, 2010, vol. 468, issue 7325, 811-814

Abstract: The hourglass: a classic embryological model for the genomics age The appearance of embryos in related species converges midway through development and diverges thereafter, a phenomenon known as the developmental hourglass. The hourglass model builds on classic observations by Karl Ernst von Baer, later popularized by Ernst Haeckel — Charles Darwin's champion in Germany. But is this 'phylotypic stage' real? Two groups use contrasting methodology to test — and provide support for — the model. Genes expressed during the phylotypic stage are both evolutionarily older and more conserved across the genus than those expressed at other stages.

Date: 2010
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DOI: 10.1038/nature09634

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