Intercalation of a new tier of transcription regulation into an ancient circuit

Lauren N. Booth, Brian B. Tuch and Alexander D. Johnson ()
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Lauren N. Booth: University of California
Brian B. Tuch: University of California
Alexander D. Johnson: University of California

Nature, 2010, vol. 468, issue 7326, 959-963

Abstract: Evolutionary change fit for purpose How new phenotypes can be introduced during evolution without a loss of fitness remains largely unexplained at the molecular level. A series of experiments comparing the molecular details of a well-known process — mating-type determination — in three ascomycete yeasts has revealed an evolutionary change in the configuration of a transcription circuit (an intercalation of a new regulator) that preserves an ancient form of regulation but produces an important novel phenotype. The new variant causes the dairy yeast Kluyveromyces lactis to mate only when nutrients are in short supply, thus taking food availability into account, a behaviour that is not found in the bakers' yeast Saccharomyces cerevisiae or the human pathogen Candida albicans.

Date: 2010
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DOI: 10.1038/nature09560

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