Crystal structure of bacterial RNA polymerase bound with a transcription inhibitor protein

Shunsuke Tagami, Shun-ichi Sekine (), Thirumananseri Kumarevel, Nobumasa Hino, Yuko Murayama, Syunsuke Kamegamori, Masaki Yamamoto, Kensaku Sakamoto and Shigeyuki Yokoyama ()
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Shunsuke Tagami: Graduate School of Science, University of Tokyo, 7-3-1 Hongo
Shun-ichi Sekine: Graduate School of Science, University of Tokyo, 7-3-1 Hongo
Thirumananseri Kumarevel: Structural and Molecular Biology Laboratory, RIKEN SPring-8 Center, Harima Institute, 1-1-1 Kouto
Nobumasa Hino: RIKEN Systems and Structural Biology Center, 1-7-22 Suehiro-cho
Yuko Murayama: Graduate School of Science, University of Tokyo, 7-3-1 Hongo
Syunsuke Kamegamori: Graduate School of Science, University of Tokyo, 7-3-1 Hongo
Masaki Yamamoto: SR Life Science Instrumentation Unit, RIKEN SPring-8 Center, Harima Institute, 1-1-1 Kouto
Kensaku Sakamoto: RIKEN Systems and Structural Biology Center, 1-7-22 Suehiro-cho
Shigeyuki Yokoyama: Graduate School of Science, University of Tokyo, 7-3-1 Hongo

Nature, 2010, vol. 468, issue 7326, 978-982

Abstract: RNA polymerase inhibition A crystal structure of bacterial RNA polymerase (RNAP) bound to the transcription inhibitor Gfh1 reveals the mechanism of inhibition by Gfh1 and shows RNAP in a novel 'ratcheted' conformation. The authors propose that the conformation they observe could be relevant for other stages of transcription such as translocation of the polymerase along DNA.

Date: 2010
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DOI: 10.1038/nature09573

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