Planar polarized actomyosin contractile flows control epithelial junction remodelling

Matteo Rauzi, Pierre-François Lenne () and Thomas Lecuit ()
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Matteo Rauzi: IBDML, UMR6216 CNRS-Université de la Méditerranée, Campus de Luminy
Pierre-François Lenne: IBDML, UMR6216 CNRS-Université de la Méditerranée, Campus de Luminy
Thomas Lecuit: IBDML, UMR6216 CNRS-Université de la Méditerranée, Campus de Luminy

Nature, 2010, vol. 468, issue 7327, 1110-1114

Abstract: Myosin-II in epithelial morphogenesis Myosin-II has a central role in generating the forces that drive cell shape changes during embryo development. Thomas Lecuit and colleagues study germ-band extension in Drosophila, in which epithelial cells undergo an ordered process of intercalation resulting in tissue extension through remodelling of cell junctions. They find that cell-junction shrinkage is driven by polarized flow of medial myosin-II pulses towards junctions, which organizes the whole process of intercalation. In addition, the flow of myosin-II is driven by the polarized distribution of E-cadherin/β-catenin/ α-catenin complexes at adherens junctions. Thus, epithelial morphogenesis is driven by polarized contractile actomyosin flows emerging from interactions between E-cadherin and actomyosin networks.

Date: 2010
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DOI: 10.1038/nature09566

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