Transcriptional activation of polycomb-repressed genes by ZRF1

Holger Richly, Luciana Rocha-Viegas, Joana Domingues Ribeiro, Santiago Demajo, Gunes Gundem, Nuria Lopez-Bigas, Tekeya Nakagawa, Sabine Rospert, Takashi Ito and Luciano Di Croce ()
Additional contact information
Holger Richly: Centre de Regulació Genòmica (CRG)/UPF
Luciana Rocha-Viegas: Centre de Regulació Genòmica (CRG)/UPF
Joana Domingues Ribeiro: Centre de Regulació Genòmica (CRG)/UPF
Santiago Demajo: Centre de Regulació Genòmica (CRG)/UPF
Gunes Gundem: Universitat Pompeu Fabra
Nuria Lopez-Bigas: Universitat Pompeu Fabra
Tekeya Nakagawa: Nagasaki University School of Medicine
Sabine Rospert: Institut für Biochemie und Molekularbiologie (ZBMZ), Universität Freiburg
Takashi Ito: Nagasaki University School of Medicine
Luciano Di Croce: Centre de Regulació Genòmica (CRG)/UPF

Nature, 2010, vol. 468, issue 7327, 1124-1128

Abstract: ZRF1 role in cell fate decisions Ubiquitination of histone H2A has been implicated in polycomb-mediated transcriptional silencing, but its precise functions are unclear. Here, the phosphoprotein ZRF1 (zuotin-related factor 1) is shown to be recruited to ubiquitinated H2A and to function in displacing polycomb-repressive complex 1 (PRC1) from chromatin to facilitate transcriptional activation. This work suggests a molecular mechanism by which polycomb-repressed genes are switched to an active state and points to a key role for ZRF1 in determining cell fate.

Date: 2010
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature09574 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:468:y:2010:i:7327:d:10.1038_nature09574

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09574

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().