Subtypes of medulloblastoma have distinct developmental origins

Paul Gibson, Yiai Tong, Giles Robinson, Margaret C. Thompson, D. Spencer Currle, Christopher Eden, Tanya A. Kranenburg, Twala Hogg, Helen Poppleton, Julie Martin, David Finkelstein, Stanley Pounds, Aaron Weiss, Zoltan Patay, Matthew Scoggins, Robert Ogg, Yanxin Pei, Zeng-Jie Yang, Sonja Brun, Youngsoo Lee, Frederique Zindy, Janet C. Lindsey, Makoto M. Taketo, Frederick A. Boop, Robert A. Sanford, Amar Gajjar, Steven C. Clifford, Martine F. Roussel, Peter J. McKinnon, David H. Gutmann, David W. Ellison, Robert Wechsler-Reya and Richard J. Gilbertson ()
Additional contact information
Paul Gibson: St Jude Children’s Research Hospital, 262 Danny Thomas Place
Yiai Tong: St Jude Children’s Research Hospital, 262 Danny Thomas Place
Giles Robinson: St Jude Children’s Research Hospital, 262 Danny Thomas Place
Margaret C. Thompson: The Cleveland Clinic
D. Spencer Currle: St Jude Children’s Research Hospital, 262 Danny Thomas Place
Christopher Eden: St Jude Children’s Research Hospital, 262 Danny Thomas Place
Tanya A. Kranenburg: St Jude Children’s Research Hospital, 262 Danny Thomas Place
Twala Hogg: St Jude Children’s Research Hospital, 262 Danny Thomas Place
Helen Poppleton: St Jude Children’s Research Hospital, 262 Danny Thomas Place
Julie Martin: St Jude Children’s Research Hospital, 262 Danny Thomas Place
David Finkelstein: Hartwell Center for Bioinformatics and Biotechnology, St Jude Children’s Research Hospital, 262 Danny Thomas Place
Stanley Pounds: St Jude Children’s Research Hospital, 262 Danny Thomas Place
Aaron Weiss: Robert Wood Johnson Medical School
Zoltan Patay: St Jude Children’s Research Hospital, 262 Danny Thomas Place
Matthew Scoggins: St Jude Children’s Research Hospital, 262 Danny Thomas Place
Robert Ogg: St Jude Children’s Research Hospital, 262 Danny Thomas Place
Yanxin Pei: Duke University Medical Center
Zeng-Jie Yang: Duke University Medical Center
Sonja Brun: Duke University Medical Center
Youngsoo Lee: St Jude Children’s Research Hospital, 262 Danny Thomas Place
Frederique Zindy: St Jude Children’s Research Hospital, 262 Danny Thomas Place
Janet C. Lindsey: Northern Institute for Cancer Research, Newcastle University
Makoto M. Taketo: Graduate School of Medicine, Kyoto University, Yoshida-Konoé-cho, Sakyo, Kyoto 606-8501, Japan
Frederick A. Boop: St Jude Children’s Research Hospital, 262 Danny Thomas Place
Robert A. Sanford: St Jude Children’s Research Hospital, 262 Danny Thomas Place
Amar Gajjar: St Jude Children’s Research Hospital, 262 Danny Thomas Place
Steven C. Clifford: Northern Institute for Cancer Research, Newcastle University
Martine F. Roussel: St Jude Children’s Research Hospital, 262 Danny Thomas Place
Peter J. McKinnon: St Jude Children’s Research Hospital, 262 Danny Thomas Place
David H. Gutmann: Washington University School of Medicine
David W. Ellison: St Jude Children’s Research Hospital, 262 Danny Thomas Place
Robert Wechsler-Reya: Duke University Medical Center
Richard J. Gilbertson: St Jude Children’s Research Hospital, 262 Danny Thomas Place

Nature, 2010, vol. 468, issue 7327, 1095-1099

Abstract: Medulloblastoma subtypes identified Medulloblastomas, a common type of malignant childhood brain tumour, are thought in the main to arise from the cerebellum, many of them involving aberrant signalling of a signalling pathway involving Sonic Hedgehog. There is substantial heterogeneity among medulloblastomas, however, and new work shows that a distinct subtype of medulloblastoma arises from the dorsal brainstem and is associated with altered Wnt signalling. Distinct molecular and clinical profiles of the subtypes have implications for future treatment. This suggests that subgroups of medulloblastoma are intrinsically different diseases, so therapeutic strategies may need to be tailored accordingly.

Date: 2010
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DOI: 10.1038/nature09587

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