The histone variant macroH2A suppresses melanoma progression through regulation of CDK8

Avnish Kapoor, Matthew S. Goldberg, Lara K. Cumberland, Kajan Ratnakumar, Miguel F. Segura, Patrick O. Emanuel, Silvia Menendez, Chiara Vardabasso, Gary LeRoy, Claudia I. Vidal, David Polsky, Iman Osman, Benjamin A. Garcia, Eva Hernando and Emily Bernstein ()
Additional contact information
Avnish Kapoor: Mount Sinai School of Medicine
Matthew S. Goldberg: Mount Sinai School of Medicine
Lara K. Cumberland: Mount Sinai School of Medicine
Kajan Ratnakumar: Mount Sinai School of Medicine
Miguel F. Segura: New York University Langone Medical Center
Patrick O. Emanuel: Mount Sinai School of Medicine
Silvia Menendez: New York University Langone Medical Center
Chiara Vardabasso: Mount Sinai School of Medicine
Gary LeRoy: Princeton University, 415 Schultz Laboratory
Claudia I. Vidal: Mount Sinai School of Medicine
David Polsky: New York University Langone Medical Center
Iman Osman: New York University Langone Medical Center
Benjamin A. Garcia: Princeton University, 415 Schultz Laboratory
Eva Hernando: New York University Langone Medical Center
Emily Bernstein: Mount Sinai School of Medicine

Nature, 2010, vol. 468, issue 7327, 1105-1109

Abstract: Histone variant lost in melanoma progression The histone variant mH2A is shown to be expressed at reduced levels in many melanomas. Loss of mH2A promotes tumour growth and metastasis, by transcriptional upregulation of CDK8, a known oncogene. This study therefore reveals a new tumour-suppression mechanism exerted by chromatin modification.

Date: 2010
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DOI: 10.1038/nature09590

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