Genetic history of an archaic hominin group from Denisova Cave in Siberia

David Reich (), Richard E. Green, Martin Kircher, Johannes Krause, Nick Patterson, Eric Y. Durand, Bence Viola (), Adrian W. Briggs, Udo Stenzel, Philip L. F. Johnson, Tomislav Maricic, Jeffrey M. Good, Tomas Marques-Bonet, Can Alkan, Qiaomei Fu, Swapan Mallick, Heng Li, Matthias Meyer, Evan E. Eichler, Mark Stoneking, Michael Richards, Sahra Talamo, Michael V. Shunkov, Anatoli P. Derevianko, Jean-Jacques Hublin, Janet Kelso, Montgomery Slatkin and Svante Pääbo ()
Additional contact information
David Reich: Harvard Medical School
Richard E. Green: Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
Martin Kircher: Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
Johannes Krause: Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
Nick Patterson: Broad Institute of MIT and Harvard
Eric Y. Durand: University of California
Bence Viola: Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
Adrian W. Briggs: Harvard Medical School
Udo Stenzel: Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
Philip L. F. Johnson: Emory University
Tomislav Maricic: Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
Jeffrey M. Good: University of Montana
Tomas Marques-Bonet: Howard Hughes Medical Institute, University of Washington
Can Alkan: Howard Hughes Medical Institute, University of Washington
Qiaomei Fu: Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
Swapan Mallick: Harvard Medical School
Heng Li: Broad Institute of MIT and Harvard
Matthias Meyer: Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
Evan E. Eichler: Howard Hughes Medical Institute, University of Washington
Mark Stoneking: Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
Michael Richards: Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
Sahra Talamo: Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
Michael V. Shunkov: Institute of Archaeology & Ethnography, Russian Academy of Sciences, Siberian Branch, Novosibirsk 630090, Russia
Anatoli P. Derevianko: Institute of Archaeology & Ethnography, Russian Academy of Sciences, Siberian Branch, Novosibirsk 630090, Russia
Jean-Jacques Hublin: Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
Janet Kelso: Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany
Montgomery Slatkin: University of California
Svante Pääbo: Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany

Nature, 2010, vol. 468, issue 7327, 1053-1060

Abstract: Abstract Using DNA extracted from a finger bone found in Denisova Cave in southern Siberia, we have sequenced the genome of an archaic hominin to about 1.9-fold coverage. This individual is from a group that shares a common origin with Neanderthals. This population was not involved in the putative gene flow from Neanderthals into Eurasians; however, the data suggest that it contributed 4–6% of its genetic material to the genomes of present-day Melanesians. We designate this hominin population ‘Denisovans’ and suggest that it may have been widespread in Asia during the Late Pleistocene epoch. A tooth found in Denisova Cave carries a mitochondrial genome highly similar to that of the finger bone. This tooth shares no derived morphological features with Neanderthals or modern humans, further indicating that Denisovans have an evolutionary history distinct from Neanderthals and modern humans.

Date: 2010
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DOI: 10.1038/nature09710

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