Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

Mariela Jaskelioff, Florian L. Muller, Ji-Hye Paik, Emily Thomas, Shan Jiang, Andrew C. Adams, Ergun Sahin, Maria Kost-Alimova, Alexei Protopopov, Juan Cadiñanos, James W. Horner, Eleftheria Maratos-Flier and Ronald A. DePinho ()
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Mariela Jaskelioff: Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School
Florian L. Muller: Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School
Ji-Hye Paik: Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School
Emily Thomas: Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School
Shan Jiang: Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School
Andrew C. Adams: Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School
Ergun Sahin: Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School
Maria Kost-Alimova: Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School
Alexei Protopopov: Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School
Juan Cadiñanos: Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School
James W. Horner: Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School
Eleftheria Maratos-Flier: Diabetes & Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School
Ronald A. DePinho: Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School

Nature, 2011, vol. 469, issue 7328, 102-106

Abstract: Anti-ageing effect of telomere restoration Loss of telomeres, the protective tips on the ends of chromosomes, causes tissue atrophy and other damage. A growing body of evidence points to telomere defects as a driver of age-associated organ decline and disease. Ronald DePinho and colleagues now show that reactivation of endogenous telomerase in mice extends telomeres, reduces DNA damage signalling, allows resumption of proliferation in quiescent cultures and eliminates degenerative phenotypes in many organs including the brain. Regenerative strategies that restore telomerase integrity may therefore be capable of slowing, halting or reversing age-related tissue degeneration — although as the authors point out, prolonged telomerase reactivation or applications in later life could provoke carcinogenesis.

Date: 2011
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DOI: 10.1038/nature09603

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