CENP-B preserves genome integrity at replication forks paused by retrotransposon LTR

Mikel Zaratiegui, Matthew W. Vaughn, Danielle V. Irvine, Derek Goto, Stephen Watt, Jürg Bähler, Benoit Arcangioli and Robert A. Martienssen ()
Additional contact information
Mikel Zaratiegui: Cold Spring Harbor Laboratory
Matthew W. Vaughn: Cold Spring Harbor Laboratory
Danielle V. Irvine: Cold Spring Harbor Laboratory
Derek Goto: Cold Spring Harbor Laboratory
Stephen Watt: University College London, Evolution & Environment, and UCL Cancer Institute, Darwin Building
Jürg Bähler: University College London, Evolution & Environment, and UCL Cancer Institute, Darwin Building
Benoit Arcangioli: Institut Pasteur, Dynamics of the Genome Unit, CNRS URA2171
Robert A. Martienssen: Cold Spring Harbor Laboratory

Nature, 2011, vol. 469, issue 7328, 112-115

Abstract: Genome integrity at replication forks Previous studies have indicated an undefined role in DNA replication for CENP-B, a DNA-binding protein associated with heterochromatin, centromeres and retrotransposon long terminal repeats (LTRs). Robert Martienssen and colleagues show that Sap1, which binds LTRs, promotes genomic instability when CENP-B activity is absent. CENP-B facilitates replication-fork progression through LTRs in a way that protects against rearrangements.

Date: 2011
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DOI: 10.1038/nature09608

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