Formation, regulation and evolution of Caenorhabditis elegans 3′UTRs

Calvin H. Jan, Robin C. Friedman, J. Graham Ruby and David P. Bartel ()
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Calvin H. Jan: Whitehead Institute for Biomedical Research
Robin C. Friedman: Whitehead Institute for Biomedical Research
J. Graham Ruby: Whitehead Institute for Biomedical Research
David P. Bartel: Whitehead Institute for Biomedical Research

Nature, 2011, vol. 469, issue 7328, 97-101

Abstract: Cleaning up the transcriptome When genes are transcribed into RNA, the polymerase extends beyond the protein-coding portion to make the 3′ untranslated region (UTR), which contains regulatory sequences and facilitates translation. Long tracts of adenine are added to the 3′ UTR, and the standard method for sequencing the transcriptome is based on hybridization to the poly(A) tail. Jan et al. report a new high-throughput approach to transcriptome sequencing that avoids the limitations of the poly(A) method, and use the new technique to provide a more accurate analysis of 3′ UTRs in the roundworm.

Date: 2011
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DOI: 10.1038/nature09616

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