Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

Moustapha Cissé, Brian Halabisky, Julie Harris, Nino Devidze, Dena B. Dubal, Binggui Sun, Anna Orr, Gregor Lotz, Daniel H. Kim, Patricia Hamto, Kaitlyn Ho, Gui-Qiu Yu and Lennart Mucke ()
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Moustapha Cissé: Gladstone Institute of Neurological Disease
Brian Halabisky: Gladstone Institute of Neurological Disease
Julie Harris: Gladstone Institute of Neurological Disease
Nino Devidze: Gladstone Institute of Neurological Disease
Dena B. Dubal: Gladstone Institute of Neurological Disease
Binggui Sun: Gladstone Institute of Neurological Disease
Anna Orr: Gladstone Institute of Neurological Disease
Gregor Lotz: Gladstone Institute of Neurological Disease
Daniel H. Kim: Gladstone Institute of Neurological Disease
Patricia Hamto: Gladstone Institute of Neurological Disease
Kaitlyn Ho: Gladstone Institute of Neurological Disease
Gui-Qiu Yu: Gladstone Institute of Neurological Disease
Lennart Mucke: Gladstone Institute of Neurological Disease

Nature, 2011, vol. 469, issue 7328, 47-52

Abstract: Abstract Amyloid-β oligomers may cause cognitive deficits in Alzheimer’s disease by impairing neuronal NMDA-type glutamate receptors, whose function is regulated by the receptor tyrosine kinase EphB2. Here we show that amyloid-β oligomers bind to the fibronectin repeats domain of EphB2 and trigger EphB2 degradation in the proteasome. To determine the pathogenic importance of EphB2 depletions in Alzheimer’s disease and related models, we used lentiviral constructs to reduce or increase neuronal expression of EphB2 in memory centres of the mouse brain. In nontransgenic mice, knockdown of EphB2 mediated by short hairpin RNA reduced NMDA receptor currents and impaired long-term potentiation in the dentate gyrus, which are important for memory formation. Increasing EphB2 expression in the dentate gyrus of human amyloid precursor protein transgenic mice reversed deficits in NMDA receptor-dependent long-term potentiation and memory impairments. Thus, depletion of EphB2 is critical in amyloid-β-induced neuronal dysfunction. Increasing EphB2 levels or function could be beneficial in Alzheimer’s disease.

Date: 2011
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DOI: 10.1038/nature09635

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