Robust multicellular computing using genetically encoded NOR gates and chemical ‘wires’

Alvin Tamsir, Jeffrey J. Tabor and Christopher A. Voigt ()
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Alvin Tamsir: University of California
Jeffrey J. Tabor: School of Pharmacy, University of California
Christopher A. Voigt: School of Pharmacy, University of California

Nature, 2011, vol. 469, issue 7329, 212-215

Abstract: Circuit training for bioengineers For the creativity of synthetic biologists to be unleashed, basic circuits must become truly interchangeable — that is, modular and scalable. Two papers in this week's Nature take steps towards that goal — one from the Escherichia coli camp and the other using yeast. Tamsir et al. harness bacterial 'quorum sensing' in E. coli and Regot et al. exploit yeast pheromone communication to achieve complex computation through communication between individual cells performing simple logic functions. Such extracellular 'chemical wiring' is one promising way to get around the difficulty of insulating different genetic circuits when these operate within a single cell.

Date: 2011
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DOI: 10.1038/nature09565

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