Integrative genomics identifies LMO1 as a neuroblastoma oncogene

Kai Wang, Sharon J. Diskin, Haitao Zhang, Edward F. Attiyeh, Cynthia Winter, Cuiping Hou, Robert W. Schnepp, Maura Diamond, Kristopher Bosse, Patrick A. Mayes, Joseph Glessner, Cecilia Kim, Edward Frackelton, Maria Garris, Qun Wang, Wendy Glaberson, Rosetta Chiavacci, Le Nguyen, Jayanti Jagannathan, Norihisa Saeki, Hiroki Sasaki, Struan F. A. Grant, Achille Iolascon, Yael P. Mosse, Kristina A. Cole, Hongzhe Li, Marcella Devoto, Patrick W. McGrady, Wendy B. London, Mario Capasso, Nazneen Rahman, Hakon Hakonarson () and John M. Maris ()
Additional contact information
Kai Wang: The Center for Applied Genomics, Children’s Hospital of Philadelphia
Sharon J. Diskin: Children’s Hospital of Philadelphia
Haitao Zhang: The Center for Applied Genomics, Children’s Hospital of Philadelphia
Edward F. Attiyeh: Children’s Hospital of Philadelphia
Cynthia Winter: Children’s Hospital of Philadelphia
Cuiping Hou: The Center for Applied Genomics, Children’s Hospital of Philadelphia
Robert W. Schnepp: Children’s Hospital of Philadelphia
Maura Diamond: Children’s Hospital of Philadelphia
Kristopher Bosse: Children’s Hospital of Philadelphia
Patrick A. Mayes: Children’s Hospital of Philadelphia
Joseph Glessner: The Center for Applied Genomics, Children’s Hospital of Philadelphia
Cecilia Kim: The Center for Applied Genomics, Children’s Hospital of Philadelphia
Edward Frackelton: The Center for Applied Genomics, Children’s Hospital of Philadelphia
Maria Garris: Children’s Hospital of Philadelphia
Qun Wang: Children’s Hospital of Philadelphia
Wendy Glaberson: The Center for Applied Genomics, Children’s Hospital of Philadelphia
Rosetta Chiavacci: The Center for Applied Genomics, Children’s Hospital of Philadelphia
Le Nguyen: Children’s Hospital of Philadelphia
Jayanti Jagannathan: Children’s Hospital of Philadelphia
Norihisa Saeki: National Cancer Center Research Institute
Hiroki Sasaki: National Cancer Center Research Institute
Struan F. A. Grant: The Center for Applied Genomics, Children’s Hospital of Philadelphia
Achille Iolascon: CEINGE Biotecnologie Avanzate
Yael P. Mosse: Children’s Hospital of Philadelphia
Kristina A. Cole: Children’s Hospital of Philadelphia
Hongzhe Li: University of Pennsylvania School of Medicine
Marcella Devoto: University of Pennsylvania School of Medicine
Patrick W. McGrady: University of Florida and Children’s Oncology Group
Wendy B. London: Dana-Farber Children’s Hospital Cancer Center and Children’s Oncology Group
Mario Capasso: CEINGE Biotecnologie Avanzate
Nazneen Rahman: Section of Cancer Genetics, Institute of Cancer Research
Hakon Hakonarson: The Center for Applied Genomics, Children’s Hospital of Philadelphia
John M. Maris: Children’s Hospital of Philadelphia

Nature, 2011, vol. 469, issue 7329, 216-220

Abstract: GWAS identifies oncogene A genome-wide association study (GWAS) has shown that single nucleotide variants within the LMO1 locus are associated with inherited susceptibility to neuroblastoma, a childhood cancer of the sympathetic nervous system. LMO1 encodes a transcriptional regulator previously linked to cancers. Acquired structural variation in the same locus is common in patients with neuroblastoma, suggesting that loci identified through GWAS approaches might also be prone to somatic alterations that influence tumour progression. Such studies could help to identify potential therapy targets and/or biomarkers of cancer aggressiveness.

Date: 2011
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DOI: 10.1038/nature09609

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