Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

Toshiro Sato, Johan H. van Es, Hugo J. Snippert, Daniel E. Stange, Robert G. Vries, Maaike van den Born, Nick Barker, Noah F. Shroyer, Marc van de Wetering and Hans Clevers ()
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Toshiro Sato: Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, the Netherlands
Johan H. van Es: Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, the Netherlands
Hugo J. Snippert: Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, the Netherlands
Daniel E. Stange: Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, the Netherlands
Robert G. Vries: Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, the Netherlands
Maaike van den Born: Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, the Netherlands
Nick Barker: Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, the Netherlands
Noah F. Shroyer: Cincinnati Children’s Hospital, Medical Center, MLC 2010
Marc van de Wetering: Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, the Netherlands
Hans Clevers: Hubrecht Institute, KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584CT Utrecht, the Netherlands

Nature, 2011, vol. 469, issue 7330, 415-418

Abstract: Paneth cells carve out a niche Paneth cells, specialized cells found in the intestinal epithelium, are known to protect stem cells by producing bactericidal compounds. Now another crucial function is reported: they provide the essential niche signals (EGF/TGFα, Notch and Wnt) for Lgr5-expressing stem cells in the small intestine. Multipotent stem cells expressing Lgr5 generate all intestinal epithelium cell types — Paneth cells included. Stem-cell niches are often seen as pre-existing sites to which stem cells migrate; this work shows that intestinal stem cells receive niche support from their own progeny.

Date: 2011
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DOI: 10.1038/nature09637

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