Atomic-level modelling of the HIV capsid

Owen Pornillos, Barbie K. Ganser-Pornillos and Mark Yeager ()
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Owen Pornillos: University of Virginia School of Medicine
Barbie K. Ganser-Pornillos: University of Virginia School of Medicine
Mark Yeager: University of Virginia School of Medicine

Nature, 2011, vol. 469, issue 7330, 424-427

Abstract: The HIV-1 capsid modelled at the atomic level The human immunodeficiency virus 1 (HIV-1) virion has a cone-shaped core composed of capsid proteins, which take either pentameric or hexameric form. Mark Yeager and colleagues had previously solved the crystal structure of the capsid hexamer. Now they provide the structure of the pentamer, which allows them to propose the first atomic-level model of the mature HIV capsid.

Date: 2011
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DOI: 10.1038/nature09640

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