Autophagy in immunity and inflammation

Beth Levine (), Noboru Mizushima and Herbert W. Virgin
Additional contact information
Beth Levine: University of Texas Southwestern Medical Center
Noboru Mizushima: Tokyo Medical and Dental University
Herbert W. Virgin: Washington University School of Medicine and Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research, Campus Box 8118, 660 South Euclid Avenue, Saint Louis, Missouri 63110, USA. virgin@wustl.edu

Nature, 2011, vol. 469, issue 7330, 323-335

Abstract: Abstract Autophagy is an essential, homeostatic process by which cells break down their own components. Perhaps the most primordial function of this lysosomal degradation pathway is adaptation to nutrient deprivation. However, in complex multicellular organisms, the core molecular machinery of autophagy — the 'autophagy proteins' — orchestrates diverse aspects of cellular and organismal responses to other dangerous stimuli such as infection. Recent developments reveal a crucial role for the autophagy pathway and proteins in immunity and inflammation. They balance the beneficial and detrimental effects of immunity and inflammation, and thereby may protect against infectious, autoimmune and inflammatory diseases.

Date: 2011
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DOI: 10.1038/nature09782

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