Ependymal cells of chordate larvae are stem-like cells that form the adult nervous system

Takeo Horie (), Ryoko Shinki, Yosuke Ogura, Takehiro G. Kusakabe, Nori Satoh and Yasunori Sasakura
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Takeo Horie: Shimoda Marine Research Center, University of Tsukuba
Ryoko Shinki: Shimoda Marine Research Center, University of Tsukuba
Yosuke Ogura: Shimoda Marine Research Center, University of Tsukuba
Takehiro G. Kusakabe: Konan University
Nori Satoh: Marine Genomics Unit, Okinawa Institute of Science and Technology Promotion Corporation
Yasunori Sasakura: Shimoda Marine Research Center, University of Tsukuba

Nature, 2011, vol. 469, issue 7331, 525-528

Abstract: Novel stem cells in the sea squirt Many aspects of the lives of the tunicates, the closest living relatives of the vertebrates, are poorly understood. It was thought that in ascidian tunicates such as the sea squirt (Ciona intestinalis), the superficially vertebrate-like central nervous system of the 'tadpole' larva degenerates to be replaced by an adult nervous system developed from scratch. Transgenesis and imaging techniques now show that this is not the case. In fact, the adult nervous system develops from stem-cell-like ependymal cells found in the larva.

Date: 2011
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DOI: 10.1038/nature09631

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