Bifidobacteria can protect from enteropathogenic infection through production of acetate

Shinji Fukuda, Hidehiro Toh, Koji Hase, Kenshiro Oshima, Yumiko Nakanishi, Kazutoshi Yoshimura, Toru Tobe, Julie M. Clarke, David L. Topping, Tohru Suzuki, Todd D. Taylor, Kikuji Itoh, Jun Kikuchi, Hidetoshi Morita, Masahira Hattori () and Hiroshi Ohno ()
Additional contact information
Shinji Fukuda: Laboratory for Epithelial Immunobiology, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
Hidehiro Toh: MetaSystems Research Team, RIKEN Advanced Science Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
Koji Hase: Laboratory for Epithelial Immunobiology, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
Kenshiro Oshima: Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan
Yumiko Nakanishi: Laboratory for Epithelial Immunobiology, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
Kazutoshi Yoshimura: Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
Toru Tobe: Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan
Julie M. Clarke: Preventative Health National Research Flagship, CSIRO Food and Nutritional Sciences, Adelaide, South Australia 5000, Australia
David L. Topping: Preventative Health National Research Flagship, CSIRO Food and Nutritional Sciences, Adelaide, South Australia 5000, Australia
Tohru Suzuki: The United Graduate School of Agricultural Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
Todd D. Taylor: MetaSystems Research Team, RIKEN Advanced Science Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
Kikuji Itoh: Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan
Jun Kikuchi: Graduate School of Nanobioscience, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
Hidetoshi Morita: School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Sagamihara, Kanagawa 229-8501, Japan
Masahira Hattori: Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8561, Japan
Hiroshi Ohno: Laboratory for Epithelial Immunobiology, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan

Nature, 2011, vol. 469, issue 7331, 543-547

Abstract: Protective effect of probiotic bacteria Bifidobacteria, sometimes used in yoghurts and other food products as 'probiotics', are natural inhabitants of the human gut and are known to protect us from infection. A possible mechanism for at least part of that protective action has now been found in the form of acetate. Oral application of a subtype of Bifidobacterium longum in mice seems to protect them from potentially fatal Escherichia coli O157:H7 by promoting host-defence mechanisms in epithelial cells.

Date: 2011
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DOI: 10.1038/nature09646

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