The challenge of new drug discovery for tuberculosis

Anil Koul (), Eric Arnoult, Nacer Lounis, Jerome Guillemont and Koen Andries
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Anil Koul: Janssen Research and Development, Johnson & Johnson, Turnhoutseweg 30, B-2340 Beerse, Belgium
Eric Arnoult: Janssen Research and Development, Johnson & Johnson, Val de Reuil 27106, Cedex, France
Nacer Lounis: Janssen Research and Development, Johnson & Johnson, Turnhoutseweg 30, B-2340 Beerse, Belgium
Jerome Guillemont: Janssen Research and Development, Johnson & Johnson, Val de Reuil 27106, Cedex, France
Koen Andries: Janssen Research and Development, Johnson & Johnson, Turnhoutseweg 30, B-2340 Beerse, Belgium

Nature, 2011, vol. 469, issue 7331, 483-490

Abstract: Sustaining the fight against TB Although vaccination has been successful in some countries, tuberculosis (TB) is more prevalent in the world today than ever before, with nearly 10 million new cases expected yearly. Anil Koul and colleagues report on the various new TB drugs and treatment regimens under development. The prospects for some of them are good, they conclude, but the TB pathogen Mycobacterium tuberculosis deploys a range of mechanisms to evade host-control measures, so it will be important to keep the drugs pipeline well supplied. In addition, successful control of TB will depend on economic and societal measures to bolster health-care infrastructure in developing countries where TB is particularly prevalent.

Date: 2011
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DOI: 10.1038/nature09657

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