Interferon-γ links ultraviolet radiation to melanomagenesis in mice

M. Raza Zaidi, Sean Davis, Frances P. Noonan, Cari Graff-Cherry, Teresa S. Hawley, Robert L. Walker, Lionel Feigenbaum, Elaine Fuchs, Lyudmila Lyakh, Howard A. Young, Thomas J. Hornyak, Heinz Arnheiter, Giorgio Trinchieri, Paul S. Meltzer, Edward C. De Fabo () and Glenn Merlino ()
Additional contact information
M. Raza Zaidi: Laboratory of Cancer Biology and Genetics, National Cancer Institute
Sean Davis: Genetics Branch, National Cancer Institute
Frances P. Noonan: Laboratory of Photobiology and Photoimmunology, Immunology and Tropical Medicine, George Washington University Medical Center
Cari Graff-Cherry: Laboratory Animal Sciences Program, National Cancer Institute
Teresa S. Hawley: Flow Cytometry Core, George Washington University Medical Center
Robert L. Walker: Genetics Branch, National Cancer Institute
Lionel Feigenbaum: Laboratory Animal Sciences Program, National Cancer Institute
Elaine Fuchs: Rockefeller University
Lyudmila Lyakh: Cancer and Inflammation Program, National Cancer Institute
Howard A. Young: Cancer and Inflammation Program, National Cancer Institute
Thomas J. Hornyak: Dermatology Branch, National Cancer Institute
Heinz Arnheiter: National Institute of Neurological Disorders and Stroke
Giorgio Trinchieri: Cancer and Inflammation Program, National Cancer Institute
Paul S. Meltzer: Genetics Branch, National Cancer Institute
Edward C. De Fabo: Laboratory of Photobiology and Photoimmunology, Immunology and Tropical Medicine, George Washington University Medical Center
Glenn Merlino: Laboratory of Cancer Biology and Genetics, National Cancer Institute

Nature, 2011, vol. 469, issue 7331, 548-553

Abstract: How UV induces melanoma Exposure to ultraviolet (UV) radiation has been implicated in melanoma formation. Glenn Merlino and colleagues now show, in a mouse model, that UVB irradiation induces the recruitment of macrophages that produce interferon-γ to promote melanoma formation. The study suggests that agents that target interferon-γ may have therapeutic potential in patients with melanoma.

Date: 2011
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DOI: 10.1038/nature09666

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