A critical role for IGF-II in memory consolidation and enhancement

Dillon Y. Chen, Sarah A. Stern, Ana Garcia-Osta, Bernadette Saunier-Rebori, Gabriella Pollonini, Dhananjay Bambah-Mukku, Robert D. Blitzer and Cristina M. Alberini ()
Additional contact information
Dillon Y. Chen: Mount Sinai School of Medicine
Sarah A. Stern: Mount Sinai School of Medicine
Ana Garcia-Osta: Mount Sinai School of Medicine
Bernadette Saunier-Rebori: Mount Sinai School of Medicine
Gabriella Pollonini: Mount Sinai School of Medicine
Dhananjay Bambah-Mukku: Mount Sinai School of Medicine
Robert D. Blitzer: Mount Sinai School of Medicine
Cristina M. Alberini: Mount Sinai School of Medicine

Nature, 2011, vol. 469, issue 7331, 491-497

Abstract: Abstract We report that, in the rat, administering insulin-like growth factor II (IGF-II, also known as IGF2) significantly enhances memory retention and prevents forgetting. Inhibitory avoidance learning leads to an increase in hippocampal expression of IGF-II, which requires the transcription factor CCAAT enhancer binding protein β and is essential for memory consolidation. Furthermore, injections of recombinant IGF-II into the hippocampus after either training or memory retrieval significantly enhance memory retention and prevent forgetting. To be effective, IGF-II needs to be administered within a sensitive period of memory consolidation. IGF-II-dependent memory enhancement requires IGF-II receptors, new protein synthesis, the function of activity-regulated cytoskeletal-associated protein and glycogen-synthase kinase 3 (GSK3). Moreover, it correlates with a significant activation of synaptic GSK3β and increased expression of GluR1 (also known as GRIA1) α-amino-3-hydroxy-5-methyl-4-isoxasolepropionic acid receptor subunits. In hippocampal slices, IGF-II promotes IGF-II receptor-dependent, persistent long-term potentiation after weak synaptic stimulation. Thus, IGF-II may represent a novel target for cognitive enhancement therapies.

Date: 2011
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature09667 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:469:y:2011:i:7331:d:10.1038_nature09667

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature09667

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().