Structural basis for site-specific ribose methylation by box C/D RNA protein complexes

Jinzhong Lin, Shaomei Lai, Ru Jia, Anbi Xu, Liman Zhang, Jing Lu and Keqiong Ye ()
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Jinzhong Lin: National Institute of Biological Sciences
Shaomei Lai: National Institute of Biological Sciences
Ru Jia: National Institute of Biological Sciences
Anbi Xu: National Institute of Biological Sciences
Liman Zhang: National Institute of Biological Sciences
Jing Lu: National Institute of Biological Sciences
Keqiong Ye: National Institute of Biological Sciences

Nature, 2011, vol. 469, issue 7331, 559-563

Abstract: Target recognition by a guide RNA Some RNAs, called guide RNAs, use their encoded sequence information to help direct a protein to where it is required. One of these RNA-protein (RNP) complexes, known as the box C/D RNP, catalyses the site-specific modification of RNAs with a 2′-O-methylation group. The structure of the full box C/D RNP complex, including three protein subunits, the guide RNA and either of two substrate RNAs, has now been determined. The structure reveals how the guide and target RNAs are aligned, and how the methyltransferase subunit, fibrillarin, facilitates positioning of the target ribose into the active site.

Date: 2011
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DOI: 10.1038/nature09688

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